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What Is It? Chloroquine is a low-cost drug that has been in use for decades
Start Preamble AGENCY: Food and Drug Administration, HHS
Hence prosecutors’ urgency—and a public interest—in concluding those trials before November
Coronavirus Disease 2019 (COVID-19) Treatment Guidelines
Randomized Clinical Trial for the Prevention of SARS-CoV-2 Infection (COVID-19) in Healthcare Personnel New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? [published online ahead of print, 2020 Mar 12] Int J Antimicrob Agents
2020
Coronavirus disease 2019 (COVID-19) has attracted worldwide attention due to its speed of progression and elevated mortality rate
Evidence for prevention of hospital admission in outpatients with COVID‐19 is very uncertain
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the global, rapidly emerging virus causing coronavirus Both chloroquine and hydroxychloroquine, however, are reportedly well-tolerated in Covid-19 patients, according to the CDC
53 While these outcomes were questioned by several experts owing to the relatively higher loading dose
Currently, at least ten clinical trials are testing chloroquine as an anti-COVID-19 therapy
Clinical trials are being conducted to identify effective drugs to treat the new coronavirus
The media have featured the antimalarials chloroquine (CQ) and hydroxychloroquine (HCQ) to treat coronavirus (COVID-19)
It is unambiguously linked to the human–human transmission of a novel coronavirus
Four trials (1942 patients: HCQ = 1271; placebo = 671) used HCQ as a prophylactic medication pre-exposure to COVID-19, two (1650 patients: HCQ = 821; placebo = 829) as a prophylactic medication post-exposure to COVID-19, three (1018 patients: HCQ = 497; placebo = 521)