Metabolism of thyroid hormone occurs primarily through sequential monodeiodination in numerous tissues, including the liver, kidney, thyroid, skin, and placenta
This was a cross-sectional study including
Metformin may affect thyroid function tests and TSH levels in patients on exogenous levothyroxine
To evaluate the effects of salicylates (ASA) on thyroid function tests (TFT's) in patients already taking phenytoin (DPH), 6 adults received a daily dose
Your guide to thyroid function tests
TRH stimulates the release of TSH from the pituitary
The following alterations in liver function tests are associated with phenytoin hepatotoxicity: elevations in serum aminotransferases, lactic dehydrogenase, alkaline phosphatase, bilirubin, and prothrombin time
Normally, low levels (less than 5 units) of TSH are sufficient to keep the normal thyroid gland functioning properly
1 Serum total and free fraction of thyroxine and triiodothyronine and urinary losses of unconjugated hormones in normal subjects and in patients treated long-term with therapeutic doses of phenytoin have been measured
Fortunately, most TFTs are straightforward to interpret and confirm the clinical impression of euthyroidism, hypothyroidism or hyperthyroidism
The practical use of thyroid function tests
such as phenytoin and aspirin and their derivatives, displace T4 from its binding sites on TBG, which spuriously lowers total serum T4 The test is valuable in the differential diagnosis of 28
Estrogens, anabolicsteroids, phenytoin, and thyroid medications may be discontinued prior to athyroxine-binding globulin (TBG) test
And any estrogen supplementation — which are often found in birth control pills — can falsely elevate total T3 and T4 levels
Moderate Potential Hazard, Moderate plausibility
52; 95%CI: - 0
Thyroid function test showed low thyroid-stimulating hormone (TSH) and normal to low fT4
Reference ranges for TFTs often vary between labs, so always refer to your local guidelines
Children taking medications for seizure control, such as valproic acid or carbamazepine may also be at increased risk for the development of hypothyroidism
5% T3 circulate bound to proteins