q12h infused over 1 h) was sampled at 1 h (peak or C max) and 12 h after linezolid dose administration (trough or C min) on two occasions (past data in red color)
The median pre-enrollment treatment for the control
600 mg PO/IV q12hr for 10-14 days Dosing Considerations Monitor: CBC count qWeek Next: Interactions Enter a drug name and linezolid All Interactions Sort By: Contraindicated
Linezolid is used to treat certain bacterial infections in many different parts of the body, including certain types of skin infections or pneumonia
This will be as an injection, or as a tablet or liquid medicine
It will not
Neonates less than 7 days: Most pre-term neonates less than 7 days of age (gestational age less than 34 weeks) have
Linezolid oral is taken by mouth
The maximum treatment duration is 28 days
It is usually given as an intravenous infusion over 30 minutes to two hours twice a day (every 12 hours) for 10 to 28 days
In cases of optic neuropathy that progressed to loss of vision, patients were treated for extended periods beyond the maximum recommended duration
If co-infection with Gram negative pathogens is known or suspected, linezolid should only be used if no other alternative treatment options are appropriate
Totals of 352 trough (minimum) and 293 peak (maximum) linezolid concentrations from
Among the 57 patients, treatment was successful, according to the WHO outcome definition , for 52 (91%); 3 were unavailable for follow-up, and 2 died with severe neurologic signs suggestive of serotonin syndrome
9 mcg/mL after single doses and 11
The main reasons for early discontinuation were gastrointestinal intolerance (n = 11) and malaise (n = 8)
• Skin rashes
, myelosuppression, peripheral neuropathy, and optic neuritis), and to achieve a peak serum linezolid level of 12–26
65 L/kg) Very
However, this medicine will not work for colds, flu, or Duration: There is evidence that prolonged courses of linezolid are associated with increased toxicity including blood disorders and optic neuropathy
Co-administration of rifampin with linezolid resulted in a 21% decrease in linezolid C max [90% CI Linezolid 600 mg PO BID Thrombocytopenia after 2 weeks
You may report side effects to FDA at 1-800-FDA-1088
Age Dose Number of children AUC 0–24SS (mg/L there were events detected even in the first 60 days, including grade 3 and 4 events
Visual blurring has been reported in some patients treated with ZYVOX for
Virtually no
98 99 Hospital-acquired (or nosocomial) pneumonia (HAP) is an important cause of morbidity and mortality despite improved prevention, antimicrobial therapy, and supportive care [ 1 ]