One unsaturated metabolite, 2-n-propyl-4-pentenoic acid (4-ene-VPA), has been proposed as a key hepatotoxic metabolite
67 mcg/mL had the greatest discriminating power (area under the curve = 0
Figure 1 Chart depicting the individual subject's serum valproic acid levels at 12 and 24 h It is observed that measuring serum VPA levels at 24 h is recommended and provides a
Normal Interface Map Interface Map COMPONENT DESCRIPTION TEST TYPE INFECTIOUS UNIT OF MEASURE NUMERIC MAP LOINC 0099791 Valproic Acid
Valproic Acid; Sex Age From Age To Type Range Range Unit : Years: 99 Years: Normal: 50 - 100: ug/mL : Years: 99 Years: Urgent > 150: ug/mL Valproic acid or valproate is a drug that is used for control of seizures
The generally acceptable range for total valproic acid used as a reference to guide therapy is 50 to 125 mcg/mL
Generic name: valproic acid (oral/injection) [ val-PRO-ik-A-sid ] Brand names: Valproate Sodium, Depakene, Depacon, Stavzor
) Container Red-stopper tube; transfer separated serum to a plastic transport tube
The nurse checks the lab values and finds a serum range for valproic acid of 200 mcg/ml
070789
Valproic acid (VPA) has been used extensively as migraine prophylaxis and in the treatment of seizure, bipolar disorder, and other psychiatric or neurological conditions
If you are registered to use the online services of your local practice, you may be able to access your results online
Talk to your provider about the meaning of your specific test results
4-Ene-Valproic Acid
What is Depakote / Valproic Acid? Depakote is an anti-epileptic drug that has been used to treat patients with epilepsy since 1983
Platelets are blood cells that help in blood clotting and wound healing — risks associated with thrombocytopenia range from no risk at all to bleeding risks and thrombosis
2
Macrocytosis, defined as a mean corpuscular volume greater than 100 fL, occurs in approximately 3 percent of the general population
Valproic acid is highly protein bound to albumin with typical values of 90–95%
This drug is usually well-tolerated; its side effects are typically mild, with hepatotoxicity being the most widely recognized one
In some cases, additional time should be allowed for additional confirmatory or additional reflex tests
Valproic Acid-Induced Liver Injury: A Case-Control Study from a Prospective Pharmacovigilance Program in a Tertiary Hospital
2
The total phenytoin reference range varies by age, as follows: Children and adults: 10-20 µg/mL [ 4] Neonates: 8-15 µg/mL
In patients with renal failure associated The generally accepted therapeutic range for total valproic acid steady-state concentrations is 50–100 μg/mL, although some clinicians suggest drug concentrations as high as 175 μg/mL with appropriate monitoring of serum concentrations and possible adverse effects