Mechanism of Action
7 L/kg
Serum: Oral (solution and immediate release): 1 to 2 hours; IV: Within 30 minutes
Theophylline is a long-acting bronchodilator
, bronchodilation) and suppression
Theophylline is a methylxanthine, a class of molecule similar to the xanthines caffeine and theobromine found in a normal diet
It must be used regularly to prevent wheezing and shortness of breath
25 mg/kg/hour; maximum dose: 507 mg/day unless serum levels indicate need
Pathogens, such as Escherichia coli (E
It has numerous pharmacological and physiological effects, including
Aminophylline is a compound of the bronchodilator theophylline with ethylenediamine in 2:1 ratio
lowest dose of inhaled anti-inflammatory corticosteroids and inhaled selective beta-2 adrenergic bronchodilators at the onset of the asthma symptoms B
Capsule (extended release): 2 hours; Tablet (immediate release): 1 to 1
Theophylline is typically used more often in dogs than cats, given variable efficacy and, perhaps, less need for
Conditions that trigger the high-pressure alarm include kinking of the ventilator tubing, bronchospasm or pulmonary embolus, mucus plugging, water in the tube, coughing or Acetazolamide is a diuretic and carbonic anhydrase inhibitor medication used to treat several illnesses
Compared to nifedipine and other medications in the dihydropyridine class, amlodipine has the longest half-life at 30 to 50 hours
Theophylline base is poorly soluble in water Onset time and potency
Beta (2)-receptor stimulation in the lung causes relaxation of bronchial smooth muscle, bronchodilation, and increased bronchial airflow
Theophylline is a methylxanthine, a class of molecule similar to the xanthines caffeine and theobromine found in a normal diet
Serum: 2 to 4 hours
24 hours
Doxofylline is a methylxanthine bronchodilator with potent bronchodilator activity comparable to that of theophylline
Half-Life Elimination <10 seconds
Terbutaline was first synthesized in 1966 12 and described in the literature in the late 1960s and early 1970s
Theophylline relaxes human airway smooth muscle in vitro through inhibition of
To evaluate their safety and efficacy, we compared epinephrine and theophylline combined with ephedrine with inhaled metaproterenol and