Levodopa and melanoma

Levodopa is a substrate for tyrosine hydroxylase, a key enzyme in the production of melanin, and melanoma tumor cells are rich in this enzyme. Patients with Parkinson’s disease (PD) generally have reduced risk of developing many types of cancers, except melanoma—a malignant tumor of melanin-producing cells in the skin

2024-03-28
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  4. PMID: 4856355; DOI: 10
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  10. Current evidence suggests that L/C can be used safely in PD
  11. Because levodopa may activate a malignant melanoma, carbidopa and