07) “Prokinetic” drugs, commonly used to treat delayed gastric emptying, have variable effects on small intestinal motility, and little is known about their effects on glucose absorption
Metoclopramide Prokinetics drugs (like metoclopramide) increase GI motility
Metoclopramide improves gastric Alteration of gastrointestinal motility is often the underlying cause for abdominal pain
Gastrointestinal motor, transport, secretory, storage, and excretory functions result from intricately balanced control mechanisms (Figure 1)
Metoclopramide stimulates and coordinates
Do not take Reglan with other medications that increase the risk of experiencing extrapyramidal reactions (eg, spasms, muscle contractions, jerky/rigid movements)
Medications to treat gastroparesis may include: Medications to stimulate the stomach muscles
Up to 60% of critically ill patients have been reported to experience GI dysmotility of some form necessitating therapeutic intervention
It is used as an adjunctive therapy in the Regulatory agencies in North America and Europe recently re-evaluated the safety of metoclopramide
They may also increase the risk of line infections in patients on long-term PN
As a result, metoclopramide augments gastrointestinal motility and enhances gastric emptying, and also increases lower esophageal sphincter
Because metoclopramide produces a transient increase in plasma aldosterone, certain patients, especially those with cirrhosis or congestive heart failure, may be at risk of developing fluid retention and volume overload