11,15,16 Plasmodium species continue to accumulate toxic heme, killing the parasite
Chloroquine increases endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV
2020 Aug;177(15):3361-3362
Suggested modes of action of chloroquine against Plasmodium falciparum parasites
Hydroxychloroquine
Although it would be aesthetically pleasing to ascribe all therapeutic effects to a single mode of action, this is not the case with the actions of
doi: 10
Chloroquine/hydroxychloroquine is an old anti-malarial drug belongs to 4-aminoquinolines
Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases, insights into the mechanism of action of these drugs are still emerging
Given the inhibition of autophagy and its immunomodulatory action, CQ shows positive efficacy against cancer
Adults with low body weight and children—Dose is based on body weight and must be determined by your doctor
In atrial fibrillation, tachyarrhythmia, or fast heart rate, can either be paroxysmal (less than 7 days) or persistent (more than 7 days)
The exact mechanism of action of metronidazole has not been fully established, Chloroquine: The metabolism of Chloroquine can be decreased when combined with Metronidazole
It is effective against chloroquine-resistant forms of Plasmodium falciparum
16 49% of the recovered dose is in the form of the metabolite GS-441524, and 10% is recovered as the unmetabolized parent compound
Amodiaquine has antimalarial activity on various Plasmodium stages similarly to that of chloroquine
knowlesi, and chloroquine-sensitive P
Valproic acid (VPA) ia as a highly prevalent medication with multifaceted therapeutic applications in various neurological and psychiatric disorders
Chloroquine developed during World War II to treat malaria
It is a white, odorless, bitter tasting, crystalline substance, freely soluble in water
Chloroquine was introduced into clinical practice in 1947 for the prophylactic treatment of malaria
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SARS-COV-2 is known to bind to human cells via the Angiotensin-Converting The many mechanisms of action of Chloroquine: to use or not to use (in COVID-19) that is the question Br J Pharmacol
Epub 2020 Jun 30