NeXagen, Inc
A variety of base modifications or 2' deoxyribose substitutions in binding-site residues
It is a bronchodilator
Cardiac dysrhythmias, seizures, and death can be seen with 80 to 100 mcg/mL levels
PDF | Species of RNA that bind with high affinity and specificity to the
Theophylline-mediated control of pre-mRNA splicing is specific
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This binding affinity is 10,000-fold greater than the RNA molecule's affinity for caffeine Theophylline (ทีโอฟิลลีน) เป็นยาในกลุ่มยารักษาโรคหอบหืด (Antiasthmatic) และโรคปอด มีฤทธิ์คลายกล้ามเนื้อบริเวณรอบ ๆ ทางเดินหายใจภายในปอด ทำให้ทางเดินหายใจ The theophylline-binding RNA aptamer displays an affinity for its cognate ligand 10,000 times that of caffeine, which differs from theophylline by only a single methyl group (Fig
Uniformly labeled AdML-Theo29AG was incubated in HeLa nuclear extract in the absence or with increasing concentrations of caffeine, and the products of The overall procedure for electrochemical system to detect theophylline is illustrated in Fig
Theophylline riboswitch is an RNA aptamer consisting of a 15-nt core sequence, which provides affinity and specificity for RNA–theophylline interaction (Fig
Simorre J
0 M theophylline, 250 μg/ml The structure provides insight into the ability of this in vitro selected RNA to discriminate theophylline from the structurally similar molecule caffeine
Take theophylline exactly as Typical dosing for Theophylline
Your doctor may adjust your dose as needed
The reference range of theophylline in the treatment of acute bronchospasm in adults is 10-15 RESULTS AND DISCUSSION RNAi induction with aptamer-fused shRNAs and its inhibition by theophylline
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
Further investigations revealed a cascading system operating beyond the ribozyme-dependent mechanism
Plasma-theophylline concentration is decreased in smokers, and by alcohol consumption