The predominantly lipophilic statins (simvastatin, fluvastatin, pitavastatin, lovastatin and atorvastatin) can easily enter cells, whereas hydrophilic statins (rosuvastatin and pravastatin) present greater hepatoselectivity
It helps lower your cholesterol, which reduces your risk of having a stroke or heart attack
0% of rosuvastatin calcium [Ca (C 22 H 27 FN 3 O 6 S) 2 ], calculated on the anhydrous and solvent-free basis
) Water : Insoluble Ethanol : Insoluble Molecular Weight Calculator: In vivo Batch: Add solvents to the product individually and Rosuvastatin (Crestor) is a fully synthetic statin that was discovered by Shionogi and commonly referred to as a "super statin," because of its high potency, together with atorvastatin (Lipitor)
5 mg/ml in a 1:1 solution of Purpose Rosuvastatin calcium (ROSCa) is a poorly soluble drug with bioavailability not exceeding 20%
The increase in solubility of rosuvastatin using solid dispersion technique mannitol, was found to 42 folds with mannitol
To identify a new drug released system and to improve its water solubility, we have 1
Solvent Max Conc
41): Water Solubility at 25 deg C (mg/L): 17
In the present work, microparticles were prepared by different techniques to enhance solubility of rosuvastatin calcium
Initially, assess rosuvastatin's solubility in hydrotropic agents including urea, mannitol, citric acid, sodium benzoate, and sodium salicylate at concentrations of 10, 20, 30, and 40% w/v
In the present work, we explore the evolution of rosuvastatin cocrystal, which may offer the synergetic physico-chemical properties of the drug
The organoleptic properties, dissolution profile, and stability of the formulation were investigated
40 mg of rosuvastatin: pink colored, oval, biconvex film coated tablets, debossed with "RS3" on one side and plain on the other side
Use: Rosuvastatin oral suspension has been used to lower serum LDL cholesterol in pediatric and adult patients
The drug is used in hyperlipidemia management
Rosuvastatin calcium (RST), a HMG-CoA Reductase inhibitor is a poorly water soluble hypolipidemic agent
A 2² factorial design was employed to study the effect of independent variables [SLS (X1) and amount of PVP K -30(X2)] The aim of this study was to enhance the solubility of rosuvastatin (RST) calcium by developing β-cyclodextrin-g-poly(2-acrylamido-2-methylpropane sulfonic acid [AMPS]) hydrogel microparticles through aqueous free-radical polymerization technique
1
RST is amorphous nature, having less aqueous solubility, belongs to biopharmaceutical classification system (BCS-II) results in low Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update
Decreasing the particle size may enhance its solubility, dissolution rate and bioavailability
66 folds enhancement in solubility was observed for hydrogel microparticles while solid dispersion system The enormous increase in rosuvastatin solubility compared to the usual formulation led to a significant development in the drug's release profile and released more than 90% of the drug within 5 Patients with de novo coronary artery disease requiring intervention were randomized to rosuvastatin 10mg (R10) or atorvastatin 20mg (A20) daily
Rosuvastatin is an inhibitor of HMG-CoA reductase that decreases serum LDL and VLDL and is used to treat atherosclerosis in clinical settings
In the current research work, the solubility of rosuvastatin calcium (ROSCa) in seven different neat solvents such as water, ethanol, 1-butanol, 2-butanol, ethylene
Rosuvastatin Calcium is the calcium salt form of rosuvastatin, a statin with antilipidemic activity
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JCT
The oral